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UCSF MIBG Protocol

January 3, 2005 | Pheochromocytoma and Paraganglioma

Here are the files for the UCSF Phase II high-dose 131I-MIBG compassionate use protocol for treatment of patients having malignant pheochromocytomas or paragangliomas

MIBG Protocol PDF

MIBG Protocol Stem Cell Harvest PDF

MIBG Protocol Consent Form PDF

In order for 131I-MIBG therapy to achieve a remission for patients with malignant pheochromocytoma, the tumors must have sufficient uptake of MIBG on diagnostic scans to allow enough 131I-MIBG to enter tumor cells. Treatment doses up to 500 mCi 131I-MIBG can be given without cryopreserved blood stem cells. At higher doses, there is a significant risk of severe suppression of the bone marrow. However, peripheral blood stem cell leukophoresis and cryopreservation has made it possible to treat patients with malignant pheochromocytoma more aggressively with 131I-MIBG, since peripheral blood stem cells may be collected in advance and reinfused in the event of prolonged myelosuppression following high-dose 131I-MIBG therapy.